Intermolecular Cooperativity of Skeletal Myosins Enhances Force Output in Myofilaments
نویسندگان
چکیده
منابع مشابه
Coordinated force generation of skeletal myosins in myofilaments through motor coupling
In contrast to processive molecular motors, skeletal myosins form a large motor ensemble for contraction of muscles against high loads. Despite numerous information on the molecular properties of skeletal myosin, its ensemble effects on collective force generation have not been rigorously clarified. Here we show 4 nm stepwise actin displacements generated by synthetic myofilaments beyond a load...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.1845